Cetuximab/C225-Induced Intracellular Trafficking of Epidermal Growth Factor Receptor
نویسندگان
چکیده
منابع مشابه
Cetuximab/C225-induced intracellular trafficking of epidermal growth factor receptor.
The monoclonal antibody C225 interacts with the ectodomain of the epidermal growth factor (EGF) receptor (EGFR) to block ligand binding and initiates receptor endocytosis and intracellular trafficking. The data herein show that C225-dependent EGFR trafficking relocalizes the receptor to the endoplasmic reticulum (ER) and nucleus. This mechanism, which also involves interaction of the C225-inter...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2009
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-09-0049